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Primidone in the Treatment of the Long QT Syndrome: QT Shortening and Ventricular Arrhythmia Suppression

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▸Requests for reprints should be addressed to Arthur J. Moss, M.D.; Box 653, University of Rochester Medical Center, Rochester, NY 14642.

Rutland, Vermont; and Rochester, New York

© 1980 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1980;93(1_Part_1):53-54. doi:10.7326/0003-4819-93-1-53
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We studied a family with the long QT syndrome. The initial case was in a patient who presented with seizures, ventricular fibrillation, and syncope. After a trial of conventional modalities of treatment including left stellate ganglionectomy, primidone (Mysoline) therapy was initiated. This drug has been successful in suppressing ventricular arrhythmias and shortening the QT interval over a 2-year follow-up period. Two additional family members with QT prolongation have been treated with primidone. During an 8-month follow-up, electrocardiographic and Holter recordings showed shortening of the QT interval.





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