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Immunoglobulin Replacement Therapy by Slow Subcutaneous Infusion

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National Institute of Allergy and Infectious Diseases; Bethesda, Maryland

Ann Intern Med. 1980;93(1_Part_1):55-56. doi:10.7326/0003-4819-93-1-55
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Alcohol fractionated immune serum globulin and fresh frozen plasma are the only generally available preparations used for replacement therapy in patients with antibody deficiency syndromes. The maximal doses that may be given are limted by the generally marked discomfort of the intramuscular injections and the large volumes of plasma that are necessary (1). Although many patients can be maintained free from infections or other symptoms despite these constraints, others continue to present problems that could potentially be relieved if greater amounts of immunoglobulin could be administered (2). We report here the successful use of a small portable pump to administer


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