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Treatment of Adult Acute Nonlymphocytic Leukemia—1980

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Section of Medical Oncology, University of Minnesota; Minneapolis, Minnesota

Ann Intern Med. 1980;93(1_Part_1):133-135. doi:10.7326/0003-4819-93-1-133
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Impressive advances in the treatment of adult acute nonlymphocytic leukemia have occurred during the last 10 years. The percentage of patients achieving complete remission has increased. The median durations of these remissions have lengthened, and the percentage of longterm survivors has risen. Ten years ago, a 25% remission rate for adults was exceptional. Today complete remission rates of more than 50% are regularly achieved in large cooperative group trials (1,2), and using combinations that include an anthracycline antibiotic (daunorubicin hydrochloride or doxorubicin hydrochloride), cytarabine, and 6-thioguanine or 6-mercaptopurine, complete remission rates of more than 80% have been reported by several


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