0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Rheumatoid Vasculitis: Effect of Cyclophosphamide on the Clinical Course and Levels of Circulating Immune Complexes

THOMAS ABEL, M.D.; BRIAN S. ANDREWS, M.D.; POLLEY H. CUNNINGHAM, M.D.; CAROLYN M. BRUNNER, M.D.; JOHN S. DAVIS IV, M.D.; and DAVID A. HORWITZ, M.D.
[+] Article and Author Information

Grant support: in part by grants from the Pratt Foundation and by divisional grant 5 RO1AM11766 from the National Institute of Arthritis, Metabolism, and Digestive Diseases.

▸Requests for reprints should be addressed to Thomas Abel, M.D.; Division of Rheumatology, Box 412, University of Virginia Medical School; Charlottesville, VA 22908.


Charlottesville, Virginia


© 1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;93(3):407-413. doi:10.7326/0003-4819-93-3-407
Text Size: A A A

A study of five patients with severe rheumatoid vasculitis treated with cyclophosphamide was undertaken to determine whether immune complexes were present in serum and if their levels correlated with disease activity and response to treatment. Circulating immune complexes were measured by various techniques including the Clq binding and Raji cell radioimmunoassays and determination of the presence of cryoglobulins. Elevated levels of circulating immune complexes, hypocomplementemia, and high titer rheumatoid factor were present during active vasculitis. Clinical and serologic remissions were induced in all patients on cyclophosphamide. In two patients in remission, a rise in rheumatoid factor titer and immune complex levels was associated with an exacerbation of vasculitis and resolved on increased cyclophosphamide dosage. The Clq binding assay and rheumatoid factor titer correlated best with clinical activity. Thus, circulating immune complexes appear to be involved in the immunopathogenesis of rheumatoid vasculitis, which can be successfully treated with cyclophosphamide.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Plasma exchange in rheumatoid vasculitis. J Rheumatol 1981 May-Jun;8(3):433-9.
Necrotizing vasculitis. J Am Acad Dermatol 1980;3(1):1-13.
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)