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5-Fluorouracil, Doxorubicin, and Mitomycin (FAM) Combination Chemotherapy for Advanced Gastric Cancer

JOHN S. MACDONALD, M.D.; PHILIP S. SCHEIN, M.D.; PAUL V. WOOLLEY, M.D.; TARILYN SMYTHE, B.S.; WINSTON UENO, M.D.; DANIEL HOTH, M.D.; FREDERICK SMITH, M.D.; MICHEL BOIRON, M.D.; CHRISTIAN GISSELBRECHT, M.D.; RENE BRUNET, M.D.; and CLAUDE LAGARDE, M.D.
[+] Article and Author Information

This work was published in part as an abstract in Proc Am Soc Clin Oncol. 1976;17:264, and in Cancer (see Reference 10).

▸Requests for reprints should be addressed to John S. Macdonald, M.D.; Cancer Therapy Evaluation Program, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 6A-17; Bethesda, MD 20205.


Washington, D.C.; Paris and Bordeaux, France


© 1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;93(4):533-536. doi:10.7326/0003-4819-93-4-533
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Sixty-two patients with advanced measurable gastric cancer were treated with a combination chemotherapy program of 5-fluorouracil, doxorubicin, and mitomycin (FAM). Forty-two percent of patients achieved an objective partial response. The median duration of remission was 9 months and the median survival for responding patients, 12.5 months. The median survival for nonresponding patients was 3.5 months; all patients were dead by 8 months after initiation of therapy. The median survival of all 62 patients treated with FAM was 5.5 months. An analysis of possible prognostic variables including initial performance status, resectability of the primary gastric tumor, and histologic differentiation of the neoplasm failed to account for differences in patient response and survival. The FAM regimen was well tolerated, producing only moderate bone marrow suppression. These results show that patients with metastatic gastric cancer can be effectively palliated with FAM chemotherapy. The efficacy of this regimen should now be tested in patients with less advanced stages of this disease.

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