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Serum Pepsinogen I as a Predictor of Stomach Cancer

ABRAHAM M. Y. NOMURA, M.D. Dr. P.H.; GRANT N. STEMMERMANN, M.D.; and I. MICHAEL SAMLOFF, M.D.
[+] Article and Author Information

Grant support: by contract N01 CP 61060 from the Biometry Branch, National Cancer Institute.

▸Requests for reprints should be addressed to Abraham M. Y. Nomura, M.D.; Japan-Hawaii Cancer Study, Kuakini Medical Center, 347 North Kuakini Street; Honolulu, HA 96817.


Honolulu, Hawaii, and Torrance, California


© 1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;93(4):537-540. doi:10.7326/0003-4819-93-4-537
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Among 7498 Japanese men who were examined from 1967 to 1970, 48 were subsequently diagnosed with stomach cancer and had premorbid stored sera available for serum pepsinogen I analysis. The median interval between serum collection and diagnosis of cancer was 44.5 months (range, 3 to 103 months). A low pepsinogen I level was found in 15 of the 48 patients with stomach cancer and in only six (6.3%) of 96 matched control subjects (p < 0.001). All 15 patients with low pepsinogen I levels belonged to the subgroup of 38 who had the intestinal-mixed-other histologic types of gastric cancer. This finding indicates that a low serum pepsinogen I level is a subclinical marker of increased risk for these histologic types of gastric cancer.

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