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Cimetidine Therapy for Severe Hypercalcemia in Two Chronic Hemodialysis Patients

[+] Article, Author, and Disclosure Information

Supported in part by grants AM 19822 and AM07205 from the National Institutes of Health; the Howard Hughes Medical Institute; and the National Kidney Foundation.

▸Requests for reprints should be addressed to Jacques J. Bourgoignie, M.D.; Division of Nephrology (R-126), University of Miami School of Medicine, P.O. Box 016960; Miami, FL 33101.

University of Miami School of Medicine; Miami, Florida. University of Geneva; Geneva, Switzerland

Ann Intern Med. 1980;93(4):573-574. doi:10.7326/0003-4819-93-4-573
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Spontaneous and persistent hypercalcemia in chronic hemodialysis patients, although rare, is usually associated with secondary hyperparathyroidism (1). When other causes of hypercalcemia are absent parathyroidectomy is indicated (2). We report two chronic hemodialysis patients with severe hypercalcemia who were successfully treated with Cimetidine for more than 6 months.

Patient A is a 22-year-old black woman with sickle cell anemia in whom proteinuria and progressive renal failure developed in 1975. Chronic hemodialysis was initiated in January 1978. In February 1979, her serum calcium levels, which had ranged from 8.0 to 9.5 mg/dL, increased progressively over a 3month period to 9.9, 11.1,


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