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Acute Meningoencephalitis After Withdrawal of Antibiotics in Whipple's Disease

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▸Requests for reprints should be addressed to Mark Feldman, M.D.; Division of Gastroenterology, Veterans Administration Hospital, 4500 South Lancaster Road; Dallas, TX 75216.

Dallas, Texas

© 1980 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1980;93(5):709-711. doi:10.7326/0003-4819-93-5-709
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A man with Whipple's disease was treated with oral penicillin (500 mg twice a day) for 2 years with eradication of bacillary organisms from the jejunum and a return of jejunal histologic findings to normal. While he was on this regimen, however, intermittent vertigo and tinnitus and decreased auditory acuity developed. Two days after penicillin was withdrawn, the patient developed acute meningoencephalitis that responded to parenteral penicillin and chloramphenicol therapy. Subsequently, central nervous system signs and symptoms and cerebrospinal fluid pleocytosis have been controlled with chronic chloramphenicol therapy. Penicillin may suppress, but not prevent, central nervous system disease in patients with otherwise successfully treated Whipple's disease.





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