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Hypouremia in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone

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The authors thank Mrs. Bertrand, Mrs. Salingret, and Mrs. Syoen, who aided in the care of the patients.

Supported by a grant from the Ministère de la Politique Scientifique (actions concertées).

▸Requests for reprints should be addressed to Guy Decaux, M.D.; Service de Médecine Interne, Hôpital Universitaire Saint-Pierre, Rue haute, 322; B-1000 Brussels, Belgium.

Ann Intern Med. 1980;93(5):716-717. doi:10.7326/0003-4819-93-5-716
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This excerpt has been provided in the absence of an abstract.

Low blood urea levels are a common finding in the syndrome of inappropriate secretion of antidiuretic hormone (1). Although they usually are attributed to body fluid dilution, some have suggested that they may also result from excessive urinary losses (2). To investigate this point we studied prospectively the relation between serum sodium levels, blood urea, and urinary urea in seven patients with the syndrome of inappropriate secretion of antidiuretic hormone. The data confirmed the suspected increase in urea urinary losses which, together with body fluid dilution, explained the low urea blood levels in our patients.

Seven patients with asymptomatic hyponatremia


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