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Minoxidil and Improvement of Renal Function in Uremic Malignant Hypertension

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Washington University School of Medicine; St. Louis, Missouri

Ann Intern Med. 1980;93(5):769-771. doi:10.7326/0003-4819-93-5-769
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The article by Mitchell and her colleagues in this issue (1) carries an important practical message: Severely compromised renal function associated with malignant hypertension can be improved by controlling the blood pressure with minoxidil. The report cites three patients, in a series of nine with malignant stages of hypertension, whose creatinine levels of 9 to 13 mg/dL before minoxidil treatment decreased by more than two thirds to 2 to 4 mg/dL during minoxidil treatment. (Note that the authors list four "improved patients," but in one the preminoxidil creatinine level was not very high and the decrease in serum creatinine was


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