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Easy Bruising, Thrombocytopenia, and Elevated Platelet Immunoglobulin G in Graves' Disease and Hashimoto's Thyroiditis

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Grant support: by Grant HL-13336-10 from the National Heart, Lung, and Blood Institute.

Presented at the 37th Annual Meeting of the American Federation for Clinical Research, May 1980, in Washington, D.C.

▸Requests for reprints should be addressed to Simon Karpatkin, M.D.; New York University Medical Center, 550 First Avenue; New York, NY 10016.

New York, New York

© 1981 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1981;94(1):27-30. doi:10.7326/0003-4819-94-1-27
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Platelet IgG levels, count, and function and easy bruising or bleeding were studied in 25 patients with Graves' disease and 12 with Hashimoto's thyroiditis (normal value for platelet IgG, 10.7 ± 4.5 ng [SD]/106 platelets). Eight of 22 patients with Graves' disease and normal platelet counts had elevated platelet IgG averaging 38 ± 4.0 ng (SEM) (range, 24 to 60). Four of 10 patients with Hashimoto's thyroiditis and normal platelet counts had elevated platelet IgG averaging 45 ± 7.2 ng (range, 27 to 66). Five patients with thrombocytopenia had platelet counts averaging 53 000 ± 12 000/µL (SEM) and elevated platelet IgG averaging 154 ± 40 ng (range, 37 to 300). Twelve of 15 patients with a history of easy bruising or bleeding had elevated platelet IgG compared to five of 22 without easy bruising (p < 0.001). Four of six with elevated platelet IgG had one or more abnormal in-vitro platelet aggregation measurements (particularly with epinephrine) compared to none of six with normal platelet IgG levels (p = 0.03). We conclude that elevated platelet IgG is associated with easy bruising and thrombocytopenia in about half of patients with Graves' disease or Hashimoto's thyroiditis.





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