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Fatal Pancytopenia Associated with the Use of Captopril

IRENE GAVRAS, M. D.; LOUIS G. GRAFF, M.D.; BURTON D. ROSE, M.D.; JOHN M. McKENNA, M.D.; HANS R. BRUNNER, M.D.; and HARALAMBOS GAVRAS, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Irene Gavras, M.D.; 80 East Concord Street R206; Boston, MA 02118.


Boston City Hospital; Boston, Massachusetts. Saint Vincent Hospital; Worcester, Massachusetts


Ann Intern Med. 1981;94(1):58-59. doi:10.7326/0003-4819-94-1-58
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This excerpt has been provided in the absence of an abstract.

Chronic inhibition of the angiotensin-converting enzyme has been used successfully in treating hypertension and congestive cardiac failure (1-4) over the past 3 years. The only oral angiotensin-converting enzyme inhibitor presently available for clinical use, captopril (Capoten, E. R. Squibb & Sons, Inc., Princeton, New Jersey), has been associated with a number of adverse reactions. These include skin rashes, sometimes preceded by fever, often accompanied by eosinophilia and lymphopenia; proteinuria, usually observed in patients with primary renal parenchymal disease; alteration or loss of taste; and recently, four cases of leukopenia with agranulocytosis (5-8). All these were transient and reversible by decreasing

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