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Cyclophosphamide-Associated Leukemia in Wegener's Granulomatosis

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▸Requests for reprints should be addressed to Gary Wheeler, M.D.; University of Louisville Health Sciences Center, Box 35260; Louisville, KY 40292

Ann Intern Med. 1981;94(3):361-362. doi:10.7326/0003-4819-94-3-361
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The efficacy of cyclophosphamide therapy in Wegener's granulomatosis is well established. Recent reports have suggested other vasculitides may also be responsive to this drug (1, 2). Long-term follow-up studies of patients with Wegener's granulomatosis have not found significant toxicity from continuous cyclophosphamide therapy (3, 4). A patient with Wegener's granulomatosis in whom the development of acute leukemia appears related to cyclophosphamide therapy is described here.

A 53-year-old woman was seen in November 1978 with a 6-week history of arthritis of the second proximal interphalangeal joint of the left hand, the third proximal interphalangeal joint of the right foot, a 7.7


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