The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Increased Factor VIII/von Willebrand Factor Antigen and von Willebrand Factor Activity in Scleroderma and in Raynaud's Phenomenon

[+] Article, Author, and Disclosure Information

Grant support: by grant AM 20571 from the National Institutes of Health and grants from the RGK Foundation and the Charlotte and Sidney Lifschultz Foundation.

▸Requests for reprints should be addressed to M. Bashar Kahaleh, M.D.; Medical University of South Carolina, 171 Ashley Avenue; Charleston, SC 29403.

Charleston, South Carolina

Ann Intern Med. 1981;94(4_Part_1):482-484. doi:10.7326/0003-4819-94-4-482
Text Size: A A A

Von Willebrand factor activity and factor VIII/von Willebrand factor (fVIII/vWf) antigen concentrations were evaluated in 17 patients with scleroderma, nine patients with Raynaud's phenomenon, and eight control volunteers. Higher circulating levels of both activities were seen: von Willebrand factor, 374% ± 40% (percent of control values) in scleroderma patients, 502% ± 104% in patients with Raynaud's phenomenon and 102% ± 6% in control subjects (p < 0. 005, scleroderma versus control); fVIII/vWf antigen, 255% ± 24% in scleroderma patients; 271% ± 46% in patients with Raynaud's phenomenon, and 99% ± 4% in control subjects (p < 0.005, scleroderma versus control). Because endothelial cells synthesize and secrete both substances, the role of endothelial injury in vitro was investigated. Wound injury induced a 344% ± 33% increase in von Willebrand factor and a 115% ± 5% increases in fVIII/vWf antigen; cold injury induced 644% ± 66% and 150% ± 10% increases, and cytotoxic endothelial injury induced 1055% ± 83% and 185% ± 20% increases. In five patients with scleroderma, cold exposure led to a further increase in both activities. The observed increase of both activities in scleroderma and Raynaud's phenomenon may reflect in-vivo endothelial injury and regeneration in these related conditions.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.