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Tocainide-Associated Interstitial Pneumonitis

GERALD M. PERLOW, M.D.; BIMAL P. JAIN, M.D.; STEPHEN G. PAUKER, M.D.; HARVEY S. ZARREN, M.D.; DANIEL C. WISTRAN, M.D.; and RALPH L. EPSTEIN, M.D.
[+] Article and Author Information

Dr. Pauker was supported in part by Research Career Development Award 1KO4GM00349 from the National Institute of General Medical Sciences, Bethesda, Maryland.

▸Requests for reprints should be addressed to Gerald M. Perlow, M.D.; 225 Boston Street; Lynn, MA 01904.


Lynn Hospital; Lynn, Massachusetts. Tufts-New England Medical Center; Boston, Massachusetts


Ann Intern Med. 1981;94(4_Part_1):489-490. doi:10.7326/0003-4819-94-4-489
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This excerpt has been provided in the absence of an abstract.

Tocainide, an investigational antiarrhythmic drug with chemical and pharmacologic properties similar to those of lidocaine, is effective when administered orally in treating ventricular arrhythmias (1-4). At present tocainide is not in clinical use in the United States or Europe, but its efficacy strongly suggests that it will soon be introduced for clinical use. Typical doses are between 400 and 800 mg every 8 hours. The commonest side effects have been anorexia, nausea, lightheadedness, tremors, sweating, hot flashes, anxiety, paresthesia, vomiting, abdominal pain, and altered vision and hearing. No pulmonary complications appear to have been reported. A single reported incident of

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