0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Reduced Serum Levels of Iα, 25-Dihydroxyvitamin D During Long-term Total Parenteral Nutrition

GORDON L. KLEIN, M.D.; RONALD L. HORST, Ph.D.; ANTHONY W. NORMAN, Ph.D.; MARVIN E. AMENT, M.D.; EDUARDO SLATOPOLSKY, M.D.; and JACK W. COBURN, M.D.
[+] Article and Author Information

Supported in part by U.S. Public Health Service Grant AM 14750 and RR 865 and Veterans Administration Funds.

Presented in part at the 7th International Conference on Calcium Regulating Hormones, September 1980, in Estes Park, Colorado.

▸Requests for reprints should be addressed to Jack W. Coburn, M.D.; Veterans Administration Wadsworth Medical Center, Sawtelle and Wilshire Blvds.; Los Angeles, CA 90073.


Los Angeles, California; Ames, Iowa; Riverside, California; and St. Louis, Missouri


© 1981 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1981;94(5):638-643. doi:10.7326/0003-4819-94-5-638
Text Size: A A A

Painful bone disease, characterized by patchy osteomalacia and inactive bone, can develop in patients treated with total parenteral nutrition for more than 3 months. Serum levels of 1α, 25-dihydroxyvitamin D (1α, 25(OH)2D), 24,25-dihydroxyvitamin D and 25-hydroxyvitamin D were measured in seven adults and five children treated with parenteral nutrition for 9 to 60 months. Serum levels of 1α,25(OH)2D were markedly reduced, while levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D were normal. Serum calcium and phosphorus levels were normal or slightly increased, and immunoreactive parathyroid hormone levels were normal or low. Renal function was normal or minimally reduced. Skeletal symptoms disappeared and serum 1α,25(OH)2D levels rose to normal in one patient when nutrient infusions were discontinued for 6 weeks. Removal of calcium from the nutrient solution for 2 to 4 days was associated with no change in serum 1α,25(OH)2D in two patients. The cause of the reduction in serum levels of 1α,25(OH)2D and its role in the pathogenesis of bone disease in these patients remain uncertain.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)