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Miconazole in Cryptococcosis and Systemic Candidiasis: A Word of Caution

Ann Intern Med. 1981;94(5):708-709. doi:10.7326/0003-4819-94-5-708
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An article in a recent issue of this journal reported the use of intravenous miconazole in cryptococcosis (1). Use of this new antifungal drug in the treatment of systemic candidiasis as well as cryptococcosis appears to be increasing. Whereas relatively few infectious disease specialists use intravenous miconazole for these indications, we believe that this drug is used much more frequently by physicians working outside the subspecialty of infectious disease. If our impression is correct, then these groups differ in the interpretation of the meager data on the efficacy of miconazole in treating these diseases. Alternatively, some physicians may be relying


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