0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Reports |

Hereditary Autoimmune Thrombocytopenic Purpura: An Immunologic and Genetic Study

SIMON KARPATKIN, M.D.; MARILENA FOTINO, M.D.; and ROBERT WINCHESTER, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Simon Karpatkin, M.D.; New York University Medical Center, 550 First Avenue; New York, NY 10016.


New York University Medical Center, New York Blood Center, and the Rockefeller University; New York, New York


Ann Intern Med. 1981;94(6):781-782. doi:10.7326/0003-4819-94-6-781
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Although numerous cases of hereditary thrombocytopenia have been reported (1), only four families (1, 2) have clinical findings consistent with the diagnosis of autoimmune thrombocytopenic purpura. None of these had antiplatelet antibody measurements of their platelets. In this report we document the first case of familial autoimmune thrombocytopenic purpura with bound platelet antibody. This family provided a unique opportunity to ascertain the immunogenetics in six related patients, four of whom developed autoimmune thrombocytopenic purpura. The mode of inheritance and potential mechanisms of action of the histocompatibility determinants that influence disease were examined. The autoimmune thrombocytopenic purpura in this family segregated

...

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)