0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Psyllium Therapy in the Irritable Bowel Syndrome: A Double-Blind Trial

GEORGE F. LONGSTRETH, M.D.; DAVID D. FOX, Ph.D.; LEE YOUKELES, M.S.; ALAN B. FORSYTHE, Ph.D.; and DONALD A. WOLOCHOW, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to George F. Longstreth, M.D.; Southern California Permanente Medical Group, 4647 Zion Avenue; San Diego, CA 92120.


San Diego and Los Angeles, California


© 1981 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1981;95(1):53-56. doi:10.7326/0003-4819-95-1-53
Text Size: A A A

A randomized, double-blind trial of a psyllium preparation was initiated in 77 patients with painful irritable bowel syndrome. Sixty patients finished and submitted symptom data for 8 weeks while taking placebo (n = 34) or psyllium (n = 26). Increase in normal stools and decrease in pain severity (p < 0.05) occurred equally in both groups. Subjective improvement was reported by 24 of 34 patients on placebo and 20 of 26 on psyllium (p > 0.05). Five symptom variables were significantly correlated (p < 0.05) with patient's subjective global assessment (R = 0.64). Discriminant analysis of Minnesota Multiphasic Personality Inventory variables yielded overall rates of correct prediction of 66.1% for whether patients got "much better" and 77.9% for whether they voluntarily dropped from the study. A major placebo effect occurs in patients with painful irritable bowel syndrome and is probably responsible for the efficacy of psyllium. Personality factors influence the magnitude of therapeutic response and whether patients discontinue treatment within 8 weeks.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)