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Therapy for Nongonococcal Urethritis: Double-Blind Randomized Comparison of Two Doses and Two Durations of Minocycline

WILLIAM R. BOWIE, M.D.; E. RUSSELL ALEXANDER, M.D.; JOHN B. STIMSON; JOHN F. FLOYD; and KING K. HOLMES, M.D., Ph.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to William R. Bowie, M.D.; University of British Columbia Department of Medicine, Vancouver General Hospital; Vancouver, British Columbia, V5Z 1M9, Canada.


Seattle, Washington


© 1981 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1981;95(3):306-311. doi:10.7326/0003-4819-95-3-306
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We treated 289 men who had nongonococcal urethritis with minocycline, 100 mg once or twice daily for 7 or 21 days. After 21 ± 7 days, urethritis persisted or recurred in 31 (27%) of 114 given 7-day therapy and only nine (8%) of 110 given 21-day therapy (p = 0.0005). However, by 49 ± 14 days, the cumulative percent rate of failure was 31% for 7-day and 30% for 21-day therapy. Thus, 21-day therapy only delayed recurrence. The higher daily dosage did not improve outcome. Urethritis persisted or recurred in 19% of men with initial Chlamydia trachomatis infection. Among men without C. trachomatis, urethritis persisted or recurred in 32% with and 52% without Ureaplasma urealyticum infection (p = 0.03). At follow-up, 79% of cases of persistent or recurrent urethritis were culture negative for C. trachomatis and U. urealyticum. The cause of C. trachomatis-negative, U. urealyticum-negative nongonococcal urethritis, which was least responsive to minocycline therapy, remains uncertain.

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