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Acebutolol-Induced Pleuropulmonary Lupus Syndrome

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▸Requests for reprints should be addressed to N. Burgess Record, Jr., M.D.; Rural Health Associates, Medical Arts Building, Routes 2 and 4; Farmington, ME 04938.

Ann Intern Med. 1981;95(3):326-327. doi:10.7326/0003-4819-95-3-326
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Drug-induced antinuclear antibodies and systemic lupus erythematosus may result from various cardiovascular drugs (1). Practolol, an early beta-adrenergic blocker, produced a lupus-like syndrome (2).

Among current beta-blockers, acebutolol seems most likely to induce antinuclear antibodies. Eight of nine acebutolol-treated patients developed antinuclear antibodies within 24 weeks (3). Three of these showed positive lupus cell preparations, but none developed clinical autoimmune disease. In a larger series, antinuclear antibodies were detected in 28.3% of 46 hypertensive patients treated with acebutolol, compared with 7.7% of 854 patients on other drugs (excluding methyldopa) (4). No clinical evidence of lupus-like syndrome was found. Among several


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