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Diagnosis and Treatment |

Drugs Five Years Later: Amikacin

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Grant support: by the Medical Research Service of the Veterans Administration.

▸Requests for reprints should be addressed to Richard D. Meyer, M.D.; Infectious Disease Section (691/111F), Veterans Administration Wadsworth Medical Center; Los Angeles, CA 90073.

© 1981 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1981;95(3):328-332. doi:10.7326/0003-4819-95-3-328
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Amikacin, the first semisynthetic aminoglycoside introduced for clinical use, has the widest spectrum of activity of these agents. This paper assesses new data on two-compartment pharmokinetics, intrathecal use, use of serum assay results, interactions with penicillins, and comparative studies of efficacy and toxicity. Indications for the use of amikacin and its role in the face of bacterial resistance to it or to other aminoglycosides are examined. The need for an agent active against most gram-negative bacilli in empiric therapy for suspected or documented bacteremia indicates the continuing importance of the aminoglycosides and, in immunocompromised patients, of amikacin.







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