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Plasma Lipid and Lipoprotein Levels with Continuous Subcutaneous Insulin Infusion in Type I Diabetes Mellitus

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Grant support: in part by grants AM18179, AM2700, 1-M01-RR0063, AM07307, and contract N01-M62219, National Institutes of Health; grant 549-8000-1, Veterans Administration Institutional Research Support Grant; and the American Heart Association. Dr. Dunn is a recipient of the Fellowship Award of the Juvenile Diabetes Foundation. Dr. Raskin was a Clinical Investigator at the Dallas Veterans Administration Medical Center.

Presented in part June 1981 at the 41st Annual Meeting of the American Diabetes Association.

▸Requests for reprints should be addressed to Philip Raskin, M.D.; Associate Professor, Department of Internal Medicine, University of Texas Health Science Center at Dallas; 5323 Harry Hines Blvd.; Dallas, TX 75235.

Dallas, Texas

© 1981 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1981;95(4):426-431. doi:10.7326/0003-4819-95-4-426
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Plasma lipid and lipoprotein-cholesterol levels were measured in 10 insulin-dependent (Type I) diabetics taking their usual dose of conventionally administered insulin during 6 months of a continuous subcutaneous insulin infusion delivered with a small, portable, battery-powered pump. With this insulin delivery system we were able to provide near normal glucoregulation 24 hours a day for the entire study. This improved glucoregulation resulted in significant reductions in total plasma cholesterol and triglyceride, and very low density and low density lipoprotein-cholesterol levels within 2 to 4 weeks of treatment. These changes persisted for the entire 6 months of observation. High density lipoprotein-cholesterol levels rose significantly after 2 months of treatment and continued to increase during the 6-month study. These changes in plasma lipid and lipoprotein-cholesterol levels in response to treatment with continuous subcutaneous insulin infusion would favorably alter the predicted risk for the development of premature atherosclerosis in these patients.





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