0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Prophylactic Trimethoprim-Sulfamethoxazole During Consolidation Chemotherapy for Acute Leukemia: A Controlled Trial

BARBARA WEISER, M.D.; MICHAEL LANGE, M.D.; MARK A. FIALK, M.D.; CAROL SINGER, M.D.; TED H. SZATROWSKI, Ph.D.; and DONALD ARMSTRONG, M.D.
[+] Article and Author Information

Grant support: Dr. Barbara Weiser was supported by the Cancer Chemotherapy Training Grant T-32CA09207 02 of the National Institutes of Health. This study was partially supported by Hoffmann-LaRoche Inc., Nutley, New Jersey.

▸Requests for reprints should be addressed to Dr. Donald Armstrong; Chief, Infectious Disease Service, Memorial Sloan-Kettering Cancer Center; 1275 York Avenue; New York, NY 10021.


New York, New York; and New Brunswick, New Jersey


© 1981 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1981;95(4):436-438. doi:10.7326/0003-4819-95-4-436
Text Size: A A A

We conducted a prospective, controlled, randomized trial of oral trimethoprim-sulfamethoxazole treatment in patients with acute leukemia receiving consolidation chemotherapy. We followed 14 treatment patients during 33 episodes and 15 control patients during 34 episodes of granulocytopenia (less than 1000 granulocytes/mm3). We found no significant difference in the incidence of febrile episodes (13 in treatment group versus 14 in control group), hospitalizations to treat fever or infection (10 versus 12), number of documented infections (eight versus 10), number of septicemias (one versus two), or mean duration of hospital stay to treat fever or infection (8.9 versus 9.2 days) in the two groups. There was little colonization with organisms resistant to trimethoprim-sulfamethoxazole, including Candida, in either group. Prophylactic trimethoprim-sulfamethoxazole did not significantly reduce the incidence of fever, hospitalization, or infection in granulocytopenic patients during consolidation chemotherapy.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)