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Peptic Ulcer Heterogeneity and Clinical Implications

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University of New Mexico; and Veterans Administration Medical Center; Albuquerque, New Mexico

Ann Intern Med. 1981;95(4):507-508. doi:10.7326/0003-4819-95-4-507
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The article by Taylor and colleagues in this issue (1) provides additional evidence that peptic ulcer, long regarded as a disease, is in fact a syndrome with many causes (2). In the past, peptic ulcers found in a variety of sites (such as the stomach or duodenum) may have seemed to be part of a continuum of focal histologic damage, the site and severity of the ulcer differing in response to various environmental influences (3). Epidemiologic studies of ulcer disease were pursued largely in the hope of identifying and controlling environmental risk factors thought to apply to a population with


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