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Trimethoprim-Sulfamethoxazole and Bacterial Infections During Leukemia Therapy

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Division of Infectious Diseases, Department of Medicine, UCLA School of Medicine, Center for the Health Sciences; Los Angeles, California

Ann Intern Med. 1981;95(4):508-509. doi:10.7326/0003-4819-95-4-508
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For physicians who treat leukemic patients the relative ease of giving cytotoxic chemotherapy is greatly over-shadowed by the challenge of managing the infections that often complicate the granulocytopenic state. Many approaches have been used to prevent bacterial infection in compromised hosts, but one of the first was prophylactic antibiotics. More than 20 years ago agents such as tetracycline were found to be neither efficacious in reducing fever and infection nor helpful in prolonging life (1). More recently, however, there has been renewed interest in antimicrobial prophylaxis as a cost-effective means of reducing infection in neutropenic patients, particularly because at least


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