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Salt, Natriuretic Hormone, and Hypertension

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Departments of Medicine, and Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University; Winston-Salem, North Carolina

Ann Intern Med. 1981;95(4):511-512. doi:10.7326/0003-4819-95-4-511
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New support for an old theory on the link between salt ingestion and hypertension is rapidly accumulating. In the early 1960s, Dahl and coworkers (1) at Brookhaven Laboratories reported development of two strains of rats in which susceptibility to hypertension was genetically determined. Rats of the "sensitive" (or S) strain ingesting a high-salt diet developed hypertension, whereas in the "resistant" (or R) strain, the same high-salt diet had no effect on blood pressure. Most importantly, a subsequent study (2) showed that susceptibility to salt-induced hypertension could be transferred from the S to the R rat through a parabiotic connection. This


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