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Warning on Use of 1980 Influenza Vaccine

Ann Intern Med. 1981;95(4):512. doi:10.7326/0003-4819-95-4-512
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This issue carries the Centers for Disease Control recommendations on use of influenza vaccine; see pp. 461-463 (1). Since that statement was sent to press, the Centers have issued a supplementary statement (2) advising against use of a 1.0-mL dose of vaccine produced in 1980:

The antigen content of influenza virus vaccine for the 1981-82 season was recently increased from 7 µg to 15 µg of hemagglutinin of each of the component strains—A/Brazil/78 (H1N1), A/Bangkok/79 (H3N2), B/Singapore/79—per 0.5-ml dose (1). Most of the data on local and systemic reactions and antibody response accumulated for the extensive clinical studies of 1976


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