The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Infections During Intensive Chemotherapy for Non-Hodgkin's Lymphoma

[+] Article, Author, and Disclosure Information

▸Requests for reprints should be addressed to Stephen C. Schimpff, M.D.; Baltimore Cancer Research Center, University of Maryland Hospital; 22 S. Greene Street; Baltimore, MD 21201.

Baltimore, Maryland

©1981 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1981;95(5):549-555. doi:10.7326/0003-4819-95-5-549
Text Size: A A A

Records of 133 infections occurring in 73 of 125 patients with late-stage non-Hodgkin's lymphoma on intensive chemotherapy programs for a median of 23 months were reviewed. Granulocytopenia, usually related to chemotherapy, was the major predisposing factor, associated with 51% of infections. The incidence of infection in chemotherapy courses associated with less than 500 granulocytes/µL was higher than those with 500 or more granulocytes/µL (p = 0.0004). Splenectomized patients tended to have a higher incidence of chemotherapy courses with an infection (p = 0.06); marrow involvement was not a significant predisposing factor to infection. The commonest sites of infection were lung, skin, and alimentary canal. Gram-negative organisms and Staphylococcus aureus caused 83% of documented infections; Pseudomonas aeruginosa was the major cause of pneumonia and bacteremia; and herpes zoster and fungi each caused only 3% of infections. Other infections associated with impaired cellular or humoral immunity were uncommon. Poor prognosis was associated with infections in granulocytopenic patients with stable or falling granulocyte counts, infection at multiple sites, and bacteremia, especially polymicrobial bacteremia.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Topic Collections
PubMed Articles
Chemotherapy-driven dysbiosis in the intestinal microbiome. Aliment Pharmacol Ther Published online Jul 6, 2015;
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.