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Prevention of Infection by Trimethoprim-Sulfamethoxazole Plus Amphotericin B in Patients with Acute Nonlymphocytic Leukaemia

ADRIAAN W. DEKKER, M.D.; MAJA ROZENBERG-ARSKA, M.D.; JAN J. SIXMA, M.D.; and JAN VERHOEF, M.D.
[+] Article and Author Information

Grant support: in part by Hoffmann-La Roche, Basel, Switzerland.

▸Requests for reprints should be addressed to Adriaan W. Dekker, M.D.; Catharijnesingel 101; 3511 GV Utrecht, The Netherlands.


Utrecht, the Netherlands


©1981 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1981;95(5):555-559. doi:10.7326/0003-4819-95-5-555
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Fifty-two patients with acute nonlymphocytic leukaemia were studied during remission induction treatment in a randomized trial to ascertain the effect of prophylactic oral trimethoprim-sulfamethoxazole on infection and fever rate. A decrease in the total number of acquired infections was found (16 infections in the group given trimethoprim-sulfamethoxazole versus 31 in the control group, p < 0.01). The number of patients without any infection in the trimethoprim-sulfamethoxazole group was 13 compared to only three in the control group (p < 0.01). Patients in the trimethoprim-sulfamethoxazole group needed parenteral antibiotics during 33% of the days they were granulocytopenic compared to 61% of these days for patients in the control group. However, six of nine bacteriologically documented infections in the trimethoprim-sulfamethoxazole group were caused by resistant microorganisms compared to two out of 20 in the control group.

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