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Adverse Hemodynamic Effects of Phentolamine in Primary Pulmonary Hypertension

MURRAY L. COHEN, M.D.; and ITZHAK KRONZON, M.D.
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▸Requests for reprints should be addressed to Itzhak Kronzon, M.D.; New York University Medical Center, Suite 2E, 560 First Avenue; New York, NY 10016.


New York University Medical Center; New York, New York


Ann Intern Med. 1981;95(5):591-592. doi:10.7326/0003-4819-95-5-591
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This excerpt has been provided in the absence of an abstract.

Primary pulmonary hypertension is a disease of unknown cause that presents with a progressive rise in pulmonary artery pressure leading almost inevitably to the development of right-sided heart failure and death. This disorder occurs most frequently in women during the second and third decade of life (1, 2).

Increased pulmonary vascular resistance associated with an increased pulmonary artery pressure and normal left-sided pressure form the physiologic basis of the diagnosis (2). The decrease in pulmonary vascular resistance in response to vasodilators seen early in the course of the disease is lost as the disease progresses (3). Wagenvoort and Wagenvoort (1)

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