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Levothyroxine Replacement Dose for Primary Hypothyroidism Decreases with Age

ROBERT L. ROSENBAUM, M.D.; and URIEL S. BARZEL, M.D.
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Presented at the 33rd Annual Meeting of the Gerontological Society of America, 22-25 November 1980, San Diego, California.

▸Requests for reprints should be addressed to Uriel S. Barzel, M.D.; Montefiore Hospital and Medical Center, 111 East 210th Street; Bronx, NY 10467.


Bronx, New York


© 1982 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1982;96(1):53-55. doi:10.7326/0003-4819-96-1-53
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We studied 23 elderly (older than 65) and 44 younger ambulatory adult patients with primary hypothyroidism to ascertain the dose of levothyroxine needed for complete replacement in relation to age. The elderly patients (average age, 75.7 years) needed an average 118 μg/d whereas the younger patients (average age, 48.1 years) needed 158 μg/d. The data indicate that thyroxine requirement may decrease continuously with age. This decrease probably reflects the progressive decrease in thyroxine degradation rate that occurs with age.

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