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Growth Hormone and Prolactin Secretion by a Tumor of the Pharyngeal Pituitary

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▸Requests for reprints should be addressed to Barry A. Warner, D.O.; Division of Endocrinology, Department of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University; Hershey, PA 17033.

The Milton S. Hershey Medical Center; Hershey, Pennsylvania.

Ann Intern Med. 1982;96(1):65-66. doi:10.7326/0003-4819-96-1-65
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Embryologic remnants of tissue with the potential of pituitary function are seen in the pharyngeal region at autopsy as a consistently normal finding in humans (1). Extrapituitary cells can produce syndromes of endocrine hypersecretion, as documented by five reports of tumors arising from embryonic remnants in the sphenoid sinus (2-6). Two of those caused the clinical syndrome of acromegaly (5, 6). However, four of five of these cases antedated development of sensitive hormone assays. We describe the case of a patient with acromegaly who had a mixed growth hormone and prolactin-secreting tumor arising within the sphenoid sinus. Endocrine testing showed


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