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Systemic Blastomycosis with Associated Diabetes Insipidus

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▸Requests for reprints should be addressed to Pamela M. Kelly, M.D.; Department of Medicine, University of Iowa Hospital and Clinics; Iowa City, IA 52242.

University of Iowa Hospital and Clinics; Iowa City, Iowa.

Ann Intern Med. 1982;96(1):66-67. doi:10.7326/0003-4819-96-1-66
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Blastomyces dermatitidis is a dimorphic fungus that can cause chronic granulomatous and suppurative disease affecting primarily the lungs, skin, bone, and male genitourinary tract. Less commonly the organism can involve almost any organ system in the body (1). I recently have seen a young man with blastomycosis proved by skin biopsy in whom diabetes insipidus developed 4 months after onset of his initial symptoms. Diabetes insipidus occasionally occurs secondarily in granulomatous diseases such as tuberculosis or histoplasmosis (2), but I have not found a single reported case of diabetes insipidus secondary to B. dermatitidis in an extensive search through the


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