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Increased Frequency of Apo E-ND Phenotype and Hyperapobetalipoproteinemia in Normolipidemic Subjects with Xanthelasmas of the Eyelids

PHILIPPE DOUSTE-BLAZY, M. D.; YVES L. MARCEL, Ph.D.; LINDA COHEN; JEAN-MARIO GIROUX, M.D.; and JEAN DAVIGNON, M.D.
[+] Article and Author Information

Grant support: from the Medical Research Council of Canada and the Quebec Heart Foundation.

Presented in part at the 53rd Annual Meeting of the American Heart Association in Miami Beach, 18 November 1980.

▸ Requests for reprints should be addressed to Jean Davignon, M.D.; Clinical Research Institute of Montreal, 110 Pine Avenue West; Montreal, Quebec, Canada H2W 1R7.


Montreal, Quebec, Canada


© 1982 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1982;96(2):164-169. doi:10.7326/0003-4819-96-2-164
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Apolipoprotein E isomorphs in very low density lipoproteins and apolipoprotein B of low density lipoproteins were measured in the plasma of normolipidemic subjects with xanthelasmas of the eyelids and in appropriate control groups. All patients tested in the experimental group had an apolipoprotein Ell to apolipoprotein EIII ratio typical of the heterozygous state for familial dysbetalipoproteinemia, a hyperapobetalipoproteinemia, or both. Some patients had concomitant atherosclerosis. This is the first report of an increased frequency of the apolipoprotein E-ND phenotype in normolipidemic xanthelasma. This condition should not be dismissed as benign; tissue lipid deposition in the absence of hyperlipidemia might be related to the presence of lipoproteins of abnormal composition with an enhanced atherogenic potential.

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