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Pulmonary Eosinophilic Granuloma: Electron Microscopic Detection of X-Bodies on Lung Lavage Cells and Transbronchoscopic Lung Biopsy in One Patient

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▸Requests for reprints should be addressed to Akira Funahashi, M.D.; Veterans Administration Medical Center, 5000 West National Avenue; Wood (Milwaukee), WI 53193.

Veterans Administration Medical Center, Wood (Milwaukee), Wisconsin; and Medical College of Wisconsin, Milwaukee, Wisconsin

Ann Intern Med. 1982;96(2):188-189. doi:10.7326/0003-4819-96-2-188
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Eosinophilic granuloma is a granulomatous disorder of uncertain cause, manifested by reactive proliferation of histiocytes that may involve the lung either as part of disseminated disease or in a "primary" form, without evidence of other organ involvement (1, 2). The diagnosis of pulmonary eosinophilic granuloma usually requires open lung biopsy, with light microscopic demonstration of nodular, interstitial lung infiltration with histiocytes and eosinophils.

Several authors have reported finding rodlike intracytoplasmic inclusion bodies within histiocytes on electron microscopy of open lung biopsy specimens from patients with pulmonary eosinophilic granuloma (2-5). These cytoplasmic structures, called "X-bodies," are believed to be a characteristic


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