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The Hepatorenal Syndrome Associated with Metastatic Angiosarcoma of the Gallbladder

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▸Requests for reprints should be addressed to S. J. Rosansky, M.D.; Wm. Jennings Bryan Dorn Veterans' Hospital; Columbia, SC 29201.

Wm. Jennings Bryan Dorn Veterans' Hospital and the University of South Carolina School of Medicine; Columbia, South Carolina

Ann Intern Med. 1982;96(2):191-192. doi:10.7326/0003-4819-96-2-191
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The Hepatorenal Syndrome is defined as unexplained renal failure occurring in a patient with cirrhosis of the liver; it rarely occurs without cirrhosis. This syndrome has been reported with hemihepatectomy (1) and neoplastic disease of the liver (2). Metastatic malignancy-associated hepatorenal syndrome in patients with otherwise normal liver parenchyma has been reported previously in only three patients (2). We describe a patient who developed the hepatorenal syndrome associated with an angiosarcoma of the gallbladder that metastasized to the liver.

A 59-year-old man was admitted with a 4-week history of right upper quadrant pain, nausea, and vomiting. The patient denied alcohol


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