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Prophylactic Granulocytes in the Neutropenic Host

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Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, California

Ann Intern Med. 1982;96(2):240-242. doi:10.7326/0003-4819-96-2-240
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One of the more sobering realities of clinical investigation is that some innovations that initially appear to be major advances later prove to be of more limited value or become identified with major hazards. This appears to be the case with granulocyte transfusions, a costly form of intervention whose therapeutic and prophylactic benefit to neutropenic patients seemed to have been established by an initial series of controlled clinical trials (1, 2). Earlier enthusiastic reports, however, did not mention the complications of transfusion-associated viral infections. This is an area now being carefully reassessed.

In this issue, Hersman and colleagues (3) have


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