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Successful Supervised Ambulatory Management of Tuberculosis Treatment Failures

REYNARD J. McDONALD, M.D.; ABDUL M. MEMON, M.D.; and LEE B. REICHMAN, M.D., M.P.H.
[+] Article and Author Information

Grant support: Contract 576444 from the New Jersey State Department of Health.

Presented in part in May 1978 at the American Thoracic Society Annual Meeting, Boston, Massachusetts.

▸Requests for reprints should be addressed to Reynard J. McDonald, M.D.; Pulmonary Division, College Hospital; 1-354, 100 Bergen Street; Newark, NJ 07103.


Newark, New Jersey


© 1982 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1982;96(3):297-302. doi:10.7326/0003-4819-96-3-297
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Twenty-one patients with long histories of failed treatment for pulmonary tuberculosis, most of whom were recalcitrant in taking medications, were treated on a primarily ambulatory basis with various antituberculosis drugs. Supervision ensured that medication was taken. Convenient, personalized, comprehensive medical care and social services were provided without cost to patients during the early phase of treatment. Management during the continuation phase was unsupervised. Fourteen patients had drug-resistant tuberculosis and 16 were either alcohol or opiate abusers. Treatment success was achieved in 19 of 21 patients with a mean follow-up of 26 months. Two patients failed to achieve a sputum-negative status for Mycobacterium tuberculosis.

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