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Increased Levels of Serum Angiotensin-Converting Enzyme Activity in Hyperthyroidism

HlDEKI YOTSUMOTO, M. D.; YASUO IMAI, M.D.; NOBUAKI KUZUYA, M.D.; HIDEMASA UCHIMURA, M.D.; and FUKASHI MATSUZAKI, M.D.
[+] Article and Author Information

Grant support: in part by a Research Grant for Specific Diseases from the Ministry of Health and Welfare of Japan.

▸Requests for reprints should be addressed to Hideki Yotsumoto, M.D.; Pulmonary Division, New England Medical Center Hospital, Box 257; 171 Harrison-Avenue; Boston, MA 02111.


Tokyo, Japan


© 1982 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1982;96(3):326-328. doi:10.7326/0003-4819-96-3-326
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Serum angiotensin-converting enzyme activity was significantly elevated in 21 patients with hyperthyroidism (65 ± 18 U/mL) as compared with levels in healthy control subjects (30 ± 9 U/mL). In eight patients treated with thionamide drugs, the enzyme activities decreased to a normal range as thyroid hormone concentrations returned to euthyroid levels. When two patients became hyperthyroid due to an insufficient maintenance dose of antithyroid drugs, the increase in the serum thyroid hormone concentration was followed by the re-elevation of serum angiotensin-converting enzyme levels with a time lag of about 2 weeks. Levels of this enzyme are increased reflecting the elevated serum thyroid hormone levels in hyperthyroidism. The hyperthyroid state should be considered when serum angiotensin-converting enzyme levels are high.

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