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Amphotericin-B-Induced Thrombocytopenia

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▸Requests for reprints should be addressed to Lawrence S. Lessin, M.D.; Director, Division of Hematology/Oncology, George Washington University Medical Center; 2150 Pennsylvania Avenue, N.W.; Washington, DC 20037.

George Washington University Medical Center; Washington, D.C.

Ann Intern Med. 1982;96(3):332-333. doi:10.7326/0003-4819-96-3-332
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This excerpt has been provided in the absence of an abstract.

Despite its toxicity amphotericin B is the drug of choice for treatment of most fungal infections. The known adverse effects, including anemia, hypokalemia, hypomagnesemia, and renal insufficiency, are generally reversible when therapy is interrupted (1). Thrombocytopenia has been noted in patients receiving amphotericin B (2). However, because thrombocytopenia occurred with concomitant chemotherapy, the presence of sepsis, or an underlying malignancy such as leukemia in relapse, a definite cause-and-effect relation between amphotericin B and thrombocytopenia could not be established.

We describe a patient with acute leukemia in complete hematologic remission who developed reversible thrombocytopenia with two courses of amphotericin B for


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