0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Research |

Heterophil Antibody in Adults with Sore Throat: Frequency and Clinical Presentation

MARK D. ARONSON, M.D.; ANTHONY L. KOMAROFF, M.D.; THEODORE M. PASS, Ph.D.; CHRISTINE T. ERVIN, R.N., M.A., M.P.H.; and WILLIAM T. BRANCH, M.D.
[+] Article and Author Information

Grant support: grant HS 02063, National Center for Health Services Research; and grants from the Esther A. and Joseph Klingenstein Foundation, the Commonwealth Fund, and the Robert Wood Johnson Foundation.

▸Requests for reprints should be addressed to Dr. Aronson; Division of General Medicine and Primary Care, Beth Israel Hospital, 330 Brookline Avenue; Boston, MA 02215.


Boston, Massachusetts


© 1982 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1982;96(4):505-508. doi:10.7326/0003-4819-96-4-505
Text Size: A A A

We studied the prevalence and the clinical and laboratory findings of infectious mononucleosis in ambulatory adult patients with the presenting symptom of sore throat. Extensive clinical data, heterophil antibody test, and differential leukocyte count were obtained prospectively for 709 patients, aged 16 to 73 years, seen in four primary care settings. Heterophil tests were positive in 15 of 709 patients (2%); four of the 15 had greater than 10% atypical lymphocytes. No heterophil-negative patient had greater than 10% atypical lymphocytes. Heterophil-positive patients had mild disease; none was older than 40 years. Of 70 symptoms and signs evaluated, four were found significantly more often (p 〈 0.005 for each) in the heterophil-positive patients: palatine petechiae, posterior auricular adenopathy, marked axillary adenopathy, and inguinal adenopathy. If any of these four easily shown physical findings was present, the likelihood of the patient having heterophil antibody was considerably increased; if absent, the probability of infectious mononucleosis was so low that not ordering a heterophil test or differential leukocyte count would have been efficient and safe.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Infectious mononucleosis: return to play. Clin Sports Med 2004;23(3):485-97, xi.
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)