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Antagonists of Vasopressor and Antidiuretic Responses to Arginine Vasopressin

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Department of Biochemistry, Medical College of Ohio, Toledo, OhioDepartment of Pharmacology, College of Physicians & Surgeons of Columbia University, New York, New York

Ann Intern Med. 1982;96(4):520-522. doi:10.7326/0003-4819-96-4-520
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In this issue Bichet and associates (1) present evidence that elevated levels of circulating vasopressin may be an important factor limiting water excretion by patients with hepatic cirrhosis. They also suggest that antagonists of the antidiuretic response would be useful in distinguishing the contribution of vasopressin to water retention from that of intrarenal factors. Such antagonists would not only be useful tools for studying the importance of endogenous vasopressin to water retention and hyponatremia in various clinical situations, but could also be valuable for treating hyponatremias.

The design and synthesis of effective in-vivo antagonists of vasopressor and antidiuretic responses to


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