The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Pergolide Mesylate: New Therapy for Parkinson Disease

[+] Article, Author, and Disclosure Information

Supported in part by the United Parkinson Foundation and the Boothroyd Foundation.

Departments of Neurological Sciences and Pharmacology, Rush-Presbyterian-St. Luke's Medical Center; Chicago, Illinois

Ann Intern Med. 1982;96(4):522-523. doi:10.7326/0003-4819-96-4-522
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

The side effects of chronic levodopa therapy are rarely as disabling as Parkinson disease itself. Many patients, however, after years of levodopa therapy at doses needed to control parkinsonism, are disabled by dyskinesias or psychoses. Others experience a progressive shortening of levodopa's effect (reduced "on" time) after each dose or sudden, freezing episodes (the "on/off" phenomenon) not related to dose. These therapeutic difficulties have encouraged a search for other antiparkinsonian agents. Because the primary neurohumoral defect in patients with Parkinson disease is loss of striatal dopamine, much research has focused on direct-acting dopamine agonists.

Pergolide mesylate, a synthetic cousin of


First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.