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Diagnosis and Treatment |

Drugs Five Years Later: Etidronate Disodium in the Treatment of Paget's Disease of Bone

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Grant support: by grants AM-03564 and AM-04501, U.S. Public Health Service.

▸Requests for reprints should be addressed to Stephen M. Krane, M.D.; Massachusetts General Hospital; Boston, MA 02114.

©1982 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1982;96(5):619-625. doi:10.7326/0003-4819-96-5-619
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Control of Paget's disease of bone has been possible through treatment with agents that decrease bone resorption; calcitonins, diphosphonates, and mithramycin. The pagetic lesion is not, however, cured. Etidronate disodium is one of the diphosphonates. The clinical improvement attained with this drug has to be set against adverse effects, of which pain is probably the most bothersome in practice. Clinical remission can last as long as 2 years after treatment is stopped.





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