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Adverse Effects of Danazol in Pregnancy

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Division of Reproductive Endocrinology, Vanderbilt University; Nashville, Tennessee

Ann Intern Med. 1982;96(5):672-673. doi:10.7326/0003-4819-96-5-672
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Danazol, an impeded androgen, anabolic steroid, and effective inhibitor of the stimulation by follicle stimulating hormone of folliculogenesis, has achieved a deserved reputation as the preferred medical treatment for endometriosis; in addition, it is effective in treating cystic breast disease and has been used to prevent hereditary angioneurotic edema and excessive menstrual blood loss in ovulating women. In a "Drugs Five Years Later" article published in this issue (1), Madanes and Farber provide a broad view of danazol's place in today's practice. Because the recommended dose of at least 600 mg/d is associated with androgenic and antiestrogenic side effects, the



pregnancy ; danazol

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