0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Serum Cortisol Levels in Cushing's Syndrome After Low- and High-Dose Dexamethasone Suppression

MICHAEL W. ASHCRAFT, M.D.; ANDRE J. VAN HERLE, M.D.; STUART L. VENER, M.D.; and DAVID L. GEFFNER, M.D.
[+] Article and Author Information

Grant support: in part by USPHS CRC Grant RR 00865 and USPHS training grant AM-07094.

▸ Requests for reprints should be addressed to Andre J. Van Herle, M.D.; UCLA School of Medicine, Department of Medicine/Endocrinology, Los Angeles, CA 90024.


Los Angeles, California


©1982 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1982;97(1):21-26. doi:10.7326/0003-4819-97-1-21
Text Size: A A A

To standardize the cutoff points of serum Cortisol values in the evaluation of Cushing's syndrome during a low- and high-dose dexamethasone suppression test, daily serum Cortisol measurements (0800 hours and 1600 hours) and urinary 17-hydroxycorticosteroids were compared (Study A). Forty-seven subjects were studied (11 normal subjects, 15 patients with Cushing's disease, five patients with adrenal adenoma, and 16 subjects with suspected Cushing's syndrome). A serum cortisol measurement at 1600 hours of more than 5μg/dL on low-dose dexamethasone suppression and more than 10 μg/dL on high-dose dexamethasone were ascertained to be nonsuppressed values. A baseline dehydroepiandrosterone-sulfate value less than 0.4 μg/ mL indicated patients with an adrenocorticol adenoma. Study B was a prospective study of 17 patients in which no urine samples were collected. Serum Cortisol levels, obtained at 1600 hours on the second day of low- and high-dose dexamethasone, accurately allowed a differential diagnosis of suspected Cushing's syndrome. Serum Cortisol measurements can replace the urinary 17hydroxycorticoid measurements in a cost-effective manner without a decrease in the degree of accuracy.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)