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Cyclophosphamide Hepatotoxicity in a Patient with Systemic Lupus Erythematosus

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▸ Requests for reprints should be addressed to Stuart A. Rosenberg, M.D.; Department of Internal Medicine, Box 412, University of Virginia Hospital; Charlottesville, VA 22908.

University of Virginia Medical School; Charlottesville, Virginia

Ann Intern Med. 1982;97(1):62-63. doi:10.7326/0003-4819-97-1-62
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CYCLOPHOSPHAMIDE (Cytoxan; Mead Johnson and Company, Evansville, Indiana) is a potent cyototoxic agent that is widely used to treat a number of autoimmune disorders in patients unresponsive to conventional therapy. Although patients with connective tissue diseases are known to develop a hepatotoxic reaction to salicylates (1, 2), cyclophosphamide has not previously been proven to cause liver damage in these patients. We report a case of a patient with systemic lupus erythematosus who developed hepatitis after treatment with cyclophosphamide, both on initial therapy and again on rechallenge with the drug. A 23-year-old black woman was found to have systemic lupus erythematosus


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Cyclophosphamide-associated hepatotoxicity. South Med J 1985;78(2):222-3.
Cyclophosphamide related hepatotoxicity. Aust N Z J Med 1993;23(4):408.
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