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The Emergence of Methicillin-Resistant Staphylococcus aureus

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University of Virginia School of Medicine; Charlottesville, Virginia

Ann Intern Med. 1982;97(3):440-442. doi:10.7326/0003-4819-97-3-440
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This issue features a series of papers on strains of Staphylococcus aureus that are resistant to multiple antimicrobial agents, most notably the penicillinase-resistant penicillins, including methicillin. These strains were recognized in Europe soon after the introduction of methicillin in 1960 (1). Outbreaks of hospital-acquired infection occurred during that time in many European institutions, where these multiply resistant strains frequently persisted as endemic nosocomial pathogens. However, similar epidemics were rarely reported from other parts of the world (2, 3). Renewed interest in multiply resistant S. aureus has been generated by numerous recent reports of outbreaks of nosocomial infection caused by these


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