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Membranous Glomerulonephritis as a Complication of Oral Gold Therapy

JUAN J. PLAZA, M.D.; GABRIEL HERRERO, M.D.; ANTONIO BARAT, Ph.D.; JUAN J. LOUTAIF, M.D.; LUIS HERNANDO, Ph.D.; PEDRO VALLADO, M.D.; and HORACIO OLIVA, Ph.D.
[+] Article and Author Information

▸Requests for reprints should be sent to Juan J. Plaza, M.D.; Servicio de Nefrologia, Fundación Jiménéz Díaz, Av. Reyes Católicos, 2; Madrid-3, Spain.


Universidad Autonoma de Madrid; Madrid, Spain


Ann Intern Med. 1982;97(4):563-564. doi:10.7326/0003-4819-97-4-563
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This excerpt has been provided in the absence of an abstract.

Parenteral gold compounds are usually successful in the treatment of patients with rheumatoid arthritis, but renal complications such as transient proteinuria and nephrotic syndrome (affecting 10% to 31% and 0.2% to 2.6% of patients, respectively) sometimes force discontinuation of the treatment (1, 2).

Auronafin (Smith Kline & French Laboratories, Philadelphia, Pennsylvania), an oral preparation containing gold (2, 3, 4, 6 tetra-O-acetyl-l-thio-B-D-glucopyranosato-s) (triethyl phosphine) has been proposed to be as effective as the injectable compounds with the additional advantage of being almost free from side effects; microscopic haematuria and proteinuria have occurred rarely. (Smith Kline & French Laboratories; data on file.)

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